How to Upload From Ancestry to Prometheus

Here at Family History Daily we've covered DNA testing for genealogy inquiry pretty extensively, simply we've always focused on beginnings reports, not health reports. This is because we've always felt that the genetic "health" information provided today, which is still very much in its infancy, could be taken out of context and possibly cause distress and defoliation to some users. In fact, some information offered by certain websites seems designed to mislead.

However, these reports are becoming more common and many more than people are taking reward of them. For this reason we accept decided to encompass 1 of the more respected options so that you take a trusted source to turn to if y'all decide to explore your own genetic health data.

Make Instant Discoveries in Your Family Tree At present

Imagine adding your family tree to a simple website and getting hundreds of new family history discoveries instantly.

MyHeritage is offering two free weeks of access to their all-encompassing drove of 12 billion historical records, as well as their matching technology that instantly connects you with new information near your ancestors. Sign up using the link below to find out what you can uncover well-nigh your family unit.

If you lot are interested in this type of reporting we encourage you be very wary most who y'all are giving your DNA data to and how it may be used. Many places now offering free genetic reports, but their history and intent is questionable. The site covered in this article has been effectually for quite a long time and has a clean record for data use, every bit well as very strict privacy and data storage limits.

Promethease is "a literature retrieval system that builds a personal Dna report based on connecting a file of DNA genotypes to the scientific findings cited in SNPedia." In fact, Promethease is a figurer program built by SNPedia for scientific enquiry. The data page about what they are and how they can be used can be found hither.

According to their website, they only store your raw DNA information for 24 hours and your written report for 45 days, to ensure proper use and privacy. The price is not free, but it is a minimal ($ten). For these reasons we have decided to cover them in this commodity. However, we strongly encourage you to read their Privacy Policy and Terms and Weather condition earlier making your own determination as to whether or non to take function.

In improver to privacy concerns, some people might be bothered by health reports equally they have the potential to reveal upsetting data near your potential wellness. Please recollect that your genes are merely one function of the picture when it comes to your bodily health and that the scientific discipline behind these reports is developing all of the time. The author of this article, Matthew Gaskill, has taken the fourth dimension to outline some warnings. Please take them seriously.

Family History Daily is Non an affiliate of Promethease and we will Not receive acquirement if yous make up one's mind to upload your results to their site. We are, notwithstanding, an chapter partner of 23andMe and they are linked to in this commodity considering they also provide wellness reports. AncestryDNA, MyHeritage Deoxyribonucleic acid and FTDNA are also linked to when they are discussed. If you lot choose to purchase a test with whatsoever of these companies after clicking on a link on our site we may earn a fee to support our work.

How to Use Promethease to Get a Low Cost Genetic Health Report

past Matthew Gaskill

This is a elementary introduction to the use of Promethease , a website which allows you to upload your raw DNA data (which can be obtained from the DNA testing company you sent your sample to – such as Ancestry, FTDNA, MyHeritage DNA or 23andMe), to receive a detailed written report of biological traits and predispositions you carry within y'all.

Your Promethease written report will tell y'all (to the caste it is possible with the express raw information provided by testing companies) whether or not you comport traits that MIGHT lead to certain medical weather. Not all diseases or disorders are covered by a Promethease written report, merely there are a surprisingly large number of them.

Here are some screenshots from a sample written report. You tin can view the entire sample hither.

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Get ii total weeks of complimentary admission to more than 12 billion genealogy records right now. You'll too gain access to the MyHeritage discoveries tool that locates information virtually your ancestors automatically when you upload or create a tree. What will yous observe about your family's past?

A Few Words of Warning Before Using Promethease

First, while the results of the Promethease written report are based on serious clinical studies and research, future findings may prove these results premature or wrong so do non accept them as absolute truth.

2nd, many sections of your health written report are explained in multipliers based on averages. For example "7x take a chance of male baldness." Does this mean that I am or Volition be baldheaded? NO. It ways that compared to the population studied (in this case, men in the United States) I take a college chance of becoming bald. I am 55 and take a full caput of hair, as does/did literally anybody in my family, alive and dead. Though baldness is hardly serious, you tin can encounter that this example can apply to more serious conditions as well.

What follows is a very of import point. Do non ignore this communication: If you are curious nigh your DNA makeup and what traits/tendencies information technology may deport, you may indeed want to upload your information to Promethease and received their medical report. All the same, I would highly recommend a few days of serious reflection before you do this.

If you lot are a person who is field of study to any type of hypochondria or excessive worry,  I would think twice earlier running my information through Promethease. If you are non a worrier, you should still give careful consideration to whether or not you wish to find out what possible medical traits you carry.

The Promethease study is not to be taken lightly.

It is also highly recommended that you talk over the results of your Prometheus report with your physician. If your doctor is not familiar with this blazon of Dna science or written report, ask he or she if they know another medical professional who is. When using Promethease,  prior knowledge and enquiry is key. Your report should be read with a level caput, with prior cognition of your ain (and family unit's) medical history forefront in your heed.

As you lot read your written report, remember this: in many cases, some of your "bad" and "skilful" results will likely be offset past their opposites. For instance, in my case, Promethease gives me a better than average take a chance of developing heart problems based on sure Deoxyribonucleic acid findings. Conversely, other Dna findings prove that I have a better than average chance of reacting positively to "good cholesterol" in a way that is a positive for my heart health. As with your Deoxyribonucleic acid genealogical findings, your Promethease results might exit you with more than questions than you had when yous began.

Why doesn't every DNA company offer medical reports?

In the last 10 years or then, the written report of Dna genealogy has exploded. Most people submit their DNA to companies for the reason of finding out more about their particular family unit and or ethnic heritage. In some cases, people submit their DNA in order to find birth parents or other long-lost relatives.

Initially, when 23andMe first advertised their Dna analysis they included a small number of examples of inherited Dna traits and /or relatively rare medical conditions for the consumer to analyze. However, in a number of instances, people jumped to the conclusion that because they had the remote genetic possibility of developing a certain disorder or disease, they were at present sure to get it or had indeed already gotten it.

For this reason and others, the United States Food and Drug Administration (FDA) prohibited 23andMe and other US-based genetic assay companies from releasing to the public any medical information based on the DNA that had been supplied to them.

Over the form of a number of years 23andMe lobbied the FDA, improved their methods and research, and in tardily 2016 was once over again immune to release a express amount of information regarding medical weather based on Dna testing.

Nevertheless, fifty-fifty today in the spring of 2018, the information released by 23andMe regarding genetic predispositions carried by their clients is withal relatively limited. The medical atmospheric condition and traits listed past them are for the nearly part very rare and cover only (at the fourth dimension of this writing) xl-two conditions/syndromes. That is non to underestimate their importance to those who might bear the traits of those disorders, but still, we are talking about a very small pct of the population at large.

In their advertising, 23andMe emphasizes the genetic ancestry and ethnic attribute of their services and the medical detection aspect of their service remains in the background. Other information regarding DNA traits has to exercise with gustation, hearing, etc. For example, information technology has been found that people with certain DNA traits find the taste of cilantro pleasant, while others do non – not exactly earth-shattering information!

However, the FDA does not have jurisdiction outside of the boundaries of the United States. So, for a number of years, users of DNA assay companies take had the power to upload their raw DNA information to websites/organizations based outside of the United States. The nigh prominent of these is Promethease.

And so, how does Promethease work?

Promethease is a byproduct of SNPedia, a wiki project designed to record all of the relevant research data becoming available regarding homo genetics.

SNP stands for single nucleotide polymorphism. What are SNP'south – or "snips"? Very simply speaking, nucleotides are the edifice blocks of both DNA and RNA. Polymorphisms are the variations within these single nucleotides. The structure of these polymorphisms determine certain traits and their likelihood of occurring.

For example, rs10805007, is nowadays in those of European descent with cerise hair. Information technology too marks an increased sensitivity to anesthetics, and possibly an increase in the likelihood of melanoma among Europeans. The "Rs" in these codes stand for "reference SNP cluster ID." Inside your Promethease results, you will exist able to click on the SNP'due south listed and read the information in greater length on SNPedia (which also lists the scientific references/papers used to gather this information).

How To Upload Your DNA to Promethease

Uploading your raw Deoxyribonucleic acid to Promethease is very fast once y'all've downloaded your raw information from your Deoxyribonucleic acid testing company of pick. For assistance with that y'all may want to read my article about using GEDmatch, which gives instructions for finding this raw information.

First, upload only the text file you lot downloaded from your Deoxyribonucleic acid testing company (not the entire .nada file). You can do this past choosing the green "upload raw data" option shown below.

Once your data is uploaded, y'all must pay x dollars to receive your report. Once payment is processed (via Paypal or credit card), you tin can open your report in your browser. Be sure to your download your study so that you can admission information technology after the 40-5 day period that Promethease stores it on their server.

When you lot receive your Promethease results, you will have the opportunity to run them through various filters in order to weed through the tremendous corporeality of information that y'all are given.

The simplest of these filters are "skillful", "bad" and "no value." Depending on whether you're an optimist or pessimist, you lot may want to expect at good first or bad first. On the "bad" side, your Promethease written report will tell you whether or not certain parts of your Deoxyribonucleic acid precondition you lot to take cancer of various types, Alzheimer's disease, stroke, coronary disease, and various mental illnesses. Remember to take this with a grain of common salt and combine this with prior knowledge. In my case, I have many indications that I will go Alzheimer'due south – I also take many indications that I won't. Additionally, no one in my family unit has e'er developed the disease.

For the purpose of this commodity, I will draw the quickest and well-nigh general style to go an overall movie of your Promethease report. Once you are familiar with the report, how the filters piece of work, and what they mean – and have go familiar with many unique terms you will notice in your inquiry — you tin move on to the more esoteric and/or hard filters, graphs and subjects.

Agreement Your Promethease Written report

Go to the acme correct of your written report and click on "categories." A divide window will appear that lists the topics within your study, a listing of medicines, general medical conditions, and ClinVar conditions (meet definitions at the end of this commodity).

The first thing I would do is Not to start looking upwards things like "cancer," or "center disease." I would look at the category called "medicine" and wait and see if whatever of the medicines I took were on the list, and/or if yous knew there were other medicines used for medical conditions that y'all have. In my case, I found that the anti-depressant I was taking before I read my Promethease report was not as effective as others I could be taking instead. In consultation with my doctor, I switched, and the result was pregnant. The medicine listed by Promethease was indeed meliorate at treating my depression.

The second thing I would practice? Go through your study and scan it – don't let yourself get too bogged downwardly in the details, and don't get all tangled up in outside studies (for at present). Make sure y'all've not only looked at your "bad" report but your "good" 1, also. If you lot do this 2 or three times, you volition find that you lot've developed an overall mental flick of your Deoxyribonucleic acid medical traits and some of the atmospheric condition that you may or may not have a predisposition for.

In my case, ane of the things I noticed was that "age-related macular degeneration" kept coming upwardly – with non only frequency simply seriousness. This status can lead to blindness. I at present get my eyes checked regularly – not just when I retrieve to every few years.

Some of your discoveries on Promethease might assistance to explain why you behave in the way you exercise. This is the whole "nature/nurture" thing. I am not one who believes that DNA "forces" you to exercise annihilation, merely it does predispose you to certain things.

Knowledge is power. If you are aware of certain behaviors in yourself, y'all tin do things to alleviate them or their frequency. In my example, I am blessed (I apply that term sarcastically) with the so-called "Warrior Gene" – some people think it'south a smashing thing to have. It is non. Believe me.

When I took the Promethease report as a whole it provided a better picture of my health and Deoxyribonucleic acid traits than if I focused on specific things. As always, use the information contained in this study in conjunction with prior knowledge of your own/family medical history. For example, I knew from family history that heart weather condition are a serious thing for me to pay attention to. Promethease reinforced this – strongly. The same with sure types of cancer that I know a parent and/or grandparent had.

In many cases, it'due south good for y'all to take some of what Promethease tells you with a grain (or two) or common salt. For case, my report states that I acquit traits that indicate the development of a certain cancer, however, the study cited for this shows that the clinical study group was Chinese men. Do I share DNA traits with Chinese men? I certainly practice – merely I differ enough to take this study at face value, and I don't panic, especially when this is the only study cited in the Promethease report.

Make sure that you read your "good" traits likewise. You will see that in many cases, Promethease cites studies that evidence certain people with certain traits react well to various things – similar practice, certain diets, etc. This is information that tin mediate some of your feeling of unease when looking at your "bad" traits.

In one case y'all are familiar with the navigation of the Promethease page and have familiarized yourself with some of the more difficult terms, practice some experimenting. Change filters, look around and use the information you glean to visit other sites. If you lot're like me, you will be amazed at the noesis you have gained nigh yourself.

My Takeaway from Promethease

Did Promethease change my life? Aye and no.

Did it make me more than aware of my medical atmospheric condition and whatsoever predispositions I might take lying within my DNA? No, non really – I already had a general idea of this from a adept knowledge of family unit history. Still, it did help me focus on areas that I need to continue in listen as I get older, like a trend towards sure types of cancer (bladder, testicular, prostate) that I already knew I was at risk for.

All things considered, I highly recommend Promethease. But bear in mind: nothing in your Promethease written report (except perhaps your claret blazon) should exist taken as complete truth. It should ever be paired with other reliable noesis and your physician's advice/input.

Please see the International Club of Genetic Genealogy'southward Wiki for a glossary of terms to help you decipher your reports.

Matthew Gaskill holds an MA in European History and writes on a variety of topics from the Medieval World to WWII to genealogy and more. A former educator, he values marvel and diligent research. He is currently working on a novel based on his own family history.

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